Endocrine Abstracts

Overt hypothyroidism (OH) and more controversially subclinical hypothyroidism (SCH) are associated with abnormal lipid metabolism and endothelial dysfunction under fasting conditions. Little data exists regarding the metabolic and vascular effects of OH or SCH under postprandial conditions.We aimed to characterize postprandial metabolism with emphasis on intestinally derived lipoproteins, HDL-cholesterol (HDL-C) and endothelial function in patients with ...

Background: Epicardial adipose tissue (EAT), the visceral fat of de myocardium, has been positively related to insulin resistance (IR), cardiovascular risk and the left ventricular myocardial mass. Whether EAT thickness in acromegaly is mediated by GH/IGF-1, IR or other factors remains to be elucidated.Objective: The aims of this study were: 1) To investigate whether EAT in patients with ACRO is linked to IR and pro-inflammatory and anti-inflammatory rel...

Introduction: Primary aldosteronism (PA) is mainly caused by unilateral aldosterone-producing adenomas (APA) or bilateral adrenal hyperplasia (BAH). Subtype differentiation relies on the invasive and technically challenging adrenal venous sampling (AVS). We recently demonstrated the potential utility of peripheral plasma steroid profiling by LC-MS/MS to distinguish APA and BAH. We tested the following hypotheses: first, if steroid profiling in combination with AVS, effectively...